2,763 results found
    1. Neuroscience

    Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

    Derya Sargin et al.
    Serotonin neurons in chronically isolated mice become less responsive to excitatory stimulation, but inhibiting a distinctive calcium-activated potassium channel can restore both neuronal activity and behavior.
    1. Neuroscience

    The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

    Paolo Campus et al.
    A top-down circuit generating from the prelimbic cortex and projecting to the paraventricular nucleus of the thalamus mediates individual differences in cue-elicited responding by affecting subcortical dopamine-dependent incentive learning.
    1. Neuroscience

    Persistent coding of outcome-predictive cue features in the rat nucleus accumbens

    Jimmie M Gmaz et al.
    Neural activity in the rat nucleus accumbens provides a rich task representation that includes not only expected outcomes, but also the specific identity of the cues that predict these outcomes.
    1. Neuroscience

    Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats

    Briac Halbout et al.
    Inhibiting ventral tegmental dopamine neurons, or their inputs to nucleus accumbens, disrupts cue-motivated reward seeking in a manner that depends on the microstructure of behavior.
    1. Structural Biology and Molecular Biophysics

    High temperature sensitivity is intrinsic to voltage-gated potassium channels

    Fan Yang, Jie Zheng
    Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.
    1. Neuroscience

    Valence-encoding in the lateral habenula arises from the entopeduncular region

    Hao Li et al.
    Lateral habenula neurons participate in motivated behavior via their activation by negative affective stimuli, a major source of which arises from the rostral entopeduncular nucleus.
    1. Neuroscience

    Optogenetic dissection of descending behavioral control in Drosophila

    Jessica Cande et al.
    Optogenetically activated individual descending neurons in Drosophila melanogaster drive varied stereotyped motor patterns that are often influenced by the animal's initial behavioral state.
    1. Neuroscience

    Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition

    Kevin M Collins et al.
    The neural circuit that regulates egg-laying behavior in nematode worms is activated by egg production, coupled to the circuit that generates movement, and inhibited by sensory feedback from egg release.
    1. Neuroscience

    Learning shapes the aversion and reward responses of lateral habenula neurons

    Daqing Wang et al.
    Neurons in the lateral habenula are activated by pain, bitterness and social defeat, and their responses are dynamically shaped by learning, suggesting a role in experience-dependent selection of behavioral actions to stressors.
    1. Neuroscience

    Sound Processing: A new role for zinc in the brain

    Brendan B McAllister, Richard H Dyck
    Certain neurons in the auditory cortex release zinc to influence how the brain processes sounds.
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