692 results found
    1. Neuroscience

    Dopamine neuron dependent behaviors mediated by glutamate cotransmission

    Susana Mingote et al.
    The conditional reduction of glutaminase in mouse dopamine neurons selectively attenuates glutamate cotransmission at phasic frequencies, revealing the role of dopamine neuron glutamate cotransmission in the attribution of motivational salience.
    1. Neuroscience

    A frontal cortex event-related potential driven by the basal forebrain

    David P Nguyen, Shih-Chieh Lin
    Contrary to the common belief that cognitive event-related potentials are generated by local activity within the cerebral cortex, it is shown that some of these potentials are modulated by subcortical inputs.
    1. Neuroscience

    Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing

    Hao Li et al.
    Rostromedial tegmental neurons encode motivational valence and opponent responses across a wide range of affective stimulus modalities, while also driving dopamine inhibition and conditioned place aversion to aversive stimuli.
  1. Research Culture: Framework for advancing rigorous research

    Walter J Koroshetz et al.
    Establishing a community of 'rigor champions' and building a comprehensive educational platform to teach the principles of rigorous science will help to ensure that the outputs of scientific research remain reliable and robust.
    1. Microbiology and Infectious Disease

    Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

    Gary S McDowell et al.
    Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
  2. Point of View: Competency-based assessment for the training of PhD students and early-career scientists

    Michael F Verderame et al.
    A method to assess the training of scientists, based on a set of 10 core competencies, is proposed.
  3. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Cancer Biology

    Reproducibility in Cancer Biology: The challenges of replication

    Interpreting the first results from the Reproducibility Project: Cancer Biology requires a highly nuanced approach.
    Editorial
    Available as:
    • HTML
    • PDF
  4. Plain-language Summaries of Research: An inside guide to eLife digests

    Stuart RF King et al.
    After summarizing over 2,400 articles in plain language, the eLife Features team shares what it has learnt about writing and editing for a broad audience.
    1. Computational and Systems Biology

    Cutting Edge: Anatomy of BioJS, an open source community for the life sciences

    Guy Yachdav et al.
    Community nurturing is the single most important factor in determining the sustainability of an open source project such as BioJS.

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