Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
A novel molecular mechanism linking a neurotrophin with a Toll-family and kinase-less Trk-like receptors provides a direct link from molecules to structural circuit plasticity and modification of behaviour.
Motor units within a pool exhibit distinct rate coding as force levels change, highlighting how gain control can transform inputs with limited bandwidth into the desired muscle force.
Andrew E Worthy, Joanna T Anderson ... Francisco J Alvarez
Major differences among the main spinal V1 inhibitory interneuron subgroups were revealed based on neurogenesis, circuit placement, and motoneuron targeting, and Foxp2-V1 interneurons were identified tightly coupled to limb control.
Stimulation of the ipsilateral motor cortex after spinal cord injury activates bilateral motor synergy and restores hindlimb movement, advancing neuroprosthetic strategies for motor recovery.
