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Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.

Zfp106 functions as an RNA binding protein, binds directly to GGGGCC RNA repeats, is required in motor neurons to prevent ALS-like neurodegeneration in mice, and can suppress neurotoxicity in an established fly model of ALS.

Ataxia, dystonia, and tremor phenotypes have distinct and generalizable cerebellar interposed nucleus spike signatures in mice, with defining features identified using a classifier model and pathogenicity tested using optogenetic manipulations.

Summary review of microRNA roles during motor neuron generation and degeneration.

Two homologous kinesin motors, KIF5A and KIF5B, have distinct functions in dendritic spine morphogenesis, and KIF5B plays a role in synaptic plasticity and memory.

Idiopathic patients along a complex motor neuron disease-dementia spectrum exhibit mRNA splicing changes that are due to multi-protein insolubility.

Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.

Stem-cell-based neural replacement, in combination with optogenetic stimulation, could represent a translationally viable therapeutic strategy to overcome atrophy and paralysis of targeted muscles in people living with amyotrophic lateral sclerosis.

Maintaining the connections between nerve cells and muscle could help to slow the progression of amyotrophic lateral sclerosis.

The most vulnerable motor units lose a fundamental firing property before the denervation of their muscle fibers in ALS mice, changing our view of the role of excitability in neurodegeneration.