1,563 results found
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

    Disi An et al.
    Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
    1. Neuroscience

    The critical role of membralin in postnatal motor neuron survival and disease

    Bo Yang et al.
    Membralin mutant mice manifest a severe and early-onset motor neuron disease with defects in endoplasmic reticulum-associated protein degradation.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee et al.
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
    1. Neuroscience

    Excitatory motor neurons are local oscillators for backward locomotion

    Shangbang Gao et al.
    Motor neurons are rhythm generators for backward locomotion.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Neuroscience

    Controlling motor neurons of every muscle for fly proboscis reaching

    Claire E McKellar et al.
    A new collection of fly strains comprehensively targets the motor neurons of the proboscis, allowing separate control of every muscle to determine how this appendage achieves flexible, directed reaching.
    1. Developmental Biology
    2. Neuroscience

    Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10

    Lalanti Venkatasubramanian et al.
    Ig domain family members DIP-alpha and Dpr10 are required in a subset of Drosophila leg motor neurons and muscles, respectively, to establish their fine terminal branching pattern and synapses.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships

    Julia L Meng et al.
    Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
    1. Developmental Biology
    2. Neuroscience

    Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

    Sebastian Poliak et al.
    The Netrin-1 and ephrin-B2 proteins act synergistically in the developing nervous system.
    1. Neuroscience

    Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep

    Juliane Schwarz, Henrik Bringmann
    A genetic analysis has identified the cholinergic SIA sublateral motor neurons, which innervate all four body wall muscles separately, as crucial regulators of turning around during sleep in Caenorhabditis elegans.

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