3,284 results found
    1. Neuroscience
    2. Developmental Biology

    Neuroendocrine modulation sustains the C. elegans forward motor state

    Maria A Lim et al.
    RID is a descending peptidergic neuron that sustains the forward motor state.
    1. Neuroscience

    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

    Barbara Commisso et al.
    The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
    1. Neuroscience

    Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

    Nathan Cermak et al.
    Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
    1. Neuroscience

    Visually-updated hand state estimates modulate the proprioceptive reflex independently of motor task requirements

    Sho Ito, Hiroaki Gomi
    Distortion and elimination of limb visual feedback affects low-level stretch reflex control, indicating the involvement of a high-level and multimodal representation of the limb state in orchestrating hierarchical sensorimotor control.
    1. Neuroscience

    Down regulation of vestibular balance stabilizing mechanisms to enable transition between motor states

    Romain Tisserand et al.
    Down regulation of the gain from the vestibular sensory sources prior to the initiation of movement is a motor control solution to overcome the reflex-stabilizing mechanisms to enable motion from a postural orientation.
    1. Neuroscience

    Corollary discharge promotes a sustained motor state in a neural circuit for navigation

    Ni Ji et al.
    A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.
    1. Structural Biology and Molecular Biophysics

    High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

    Zhiguo Shang et al.
    Microtubule attachment fundamentally modifies kinesin's behavior by triggering a ‘clamshell’ opening of the nucleotide cleft, subsequently reversed by ATP binding, that couples to cargo translocation.
    1. Neuroscience

    AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae

    Mohini Sengupta, Vatsala Thirumalai
    In vivo recordings in unanesthetized zebrafish larvae show that Purkinje neurons have two stable membrane potential states and that climbing fiber inputs can toggle them to up states during motor episodes.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Neuroscience

    State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

    Amanda M Willard et al.
    The transition in basal ganglia output from the healthy to the diseased state is biphasic, stereotyped across models, and suggests key time points for delivering therapeutic interventions.

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