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    1. Genetics and Genomics
    2. Medicine

    Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

    Lianlei Wang, Sen Zhao ... Nan Wu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice

    Amol Bhandare, Joseph van de Wiel ... Nicholas Dale
    Recordings from brainstem nuclei involved in chemosensory regulation of breathing in awake freely behaving mice show different complementary types of neuronal responses to hypercapnia in the retrotrapezoid nucleus and the rostral medullary raphe.
    1. Developmental Biology
    2. Evolutionary Biology

    Metamorphosis of memory circuits in Drosophila reveals a strategy for evolving a larval brain

    James W Truman, Jacquelyn Price ... Tzumin Lee
    The mushroom body neuropils of the larval brain have regions that share neurons and functions with the adult and larval-specific regions built with 'doomed' neurons or cells that trans-differentiate for temporary larval function before assuming their adult phenotypes at metamorphosis.
    1. Neuroscience

    Adaptation of spontaneous activity in the developing visual cortex

    Marina E Wosniack, Jan H Kirchner ... Julijana Gjorgjieva
    To generate stable and robust connectivity refinements, the amplitude of spontaneous activity events in the developing visual cortex adapts to the recent history of cortical activation.
    1. Neuroscience

    Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

    Hirofumi Fujita, Takashi Kodama, Sascha du Lac
    Medial cerebellar nucleus comprises five major types of excitatory projection neurons differentially connected with specific subsets of inferior olive neurons, Purkinje cells, and somatomotor, oromotor, positional-autonomic, orienting and arousal circuits.
    1. Neuroscience

    Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

    Hadeel Alyenbaawi, Richard Kanyo ... W Ted Allison
    A traumatic brain injury model is invented for larval zebrafish and applied to a new fluorescent 'tauopathy reporter fish', revealing a role for seizures in progression towards dementias.
    1. Neuroscience

    Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats

    Silvia Cardani, Tara A Janes ... Silvia Pagliardini
    Knockdown of PHOX2B in the chemosensitive area of the retrotrapezoid nucleus of adult rats reduces CO2 responses and the expression of the proton sensors TASK2 and GPR4.
    1. Neuroscience

    An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

    Niraja Ramesh, Marc Escher ... Stephan J Sigrist
    An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.
    1. Neuroscience

    Toolkits for detailed and high-throughput interrogation of synapses in C. elegans

    Maryam Majeed, Haejun Han ... Hang Lu
    An imaging pipeline together with a collection of transgenic nematode strains provide a strategy to visualize and properly quantify synaptic connectivity in the C. elegans brain.
    1. Cell Biology
    2. Neuroscience

    Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

    Friederike E Kohrs, Ilsa-Maria Daumann ... P Robin Hiesinger
    The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.