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    1. Neuroscience

    The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity

    Chad W Sauvola, Yulia Akbergenova ... J Troy Littleton
    Loss of the decoy SNARE Tomosyn enhances synaptic vesicle docking and neurotransmitter release and regulates release and plasticity differences between tonic and phasic motoneurons in Drosophila.
    1. Developmental Biology
    2. Neuroscience

    Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

    Durafshan Sakeena Syed, Swetha B.M. Gowda ... K VijayRaghavan
    Signaling from glia and nerves regulate the development of axonal and dendritic motor neuron architecture, needed for walking in the fruit fly species Drosophila.
    1. Neuroscience

    Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

    Ying Wang, Wei Wu ... Xiao-Ming Xu
    Retrograde transport of NT-3 stimulated the reorganization of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, along with improved behavioral recovery.
    1. Neuroscience

    NOVA2-mediated RNA regulation is required for axonal pathfinding during development

    Yuhki Saito, Soledad Miranda-Rottmann ... Robert B Darnell
    The RNA-binding protein NOVA2 coordinately regulates the alternative splicing of key components in axon guidance and outgrowth pathways, with severe functional consequences.
    1. Neuroscience

    Neuronal connectome of a sensory-motor circuit for visual navigation

    Nadine Randel, Albina Asadulina ... Gáspár Jékely
    Three-dimensional mapping of the neural circuitry that controls movement of a marine worm in response to light provides insights into the evolution of complex visual systems.
    1. Neuroscience

    Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

    Lasse Christiansen, MA Urbin ... Monica A Perez
    Acute intermittent hypoxia is a noninvasive approach that enhances corticospinal function in humans, likely through alterations in corticospinal-motoneuronal synaptic transmission.
    1. Neuroscience

    Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS

    Éric Martineau, Adriana Di Polo ... Richard Robitaille
    Motor axons undergo dynamic branch-specific changes for weeks before complete neuronal degeneration in a model of amyotrophic lateral sclerosis, highlighting the importance of peripheral factors, intrinsic and extrinsic to motoneurons.
    1. Neuroscience

    Gap junction-mediated glycinergic inhibition ensures precise temporal patterning in vocal behavior

    Boris P Chagnaud, Jonathan T Perelmuter ... Andrew H Bass
    Inhibition provides a means for achieving temporal precision for rapid modulation of an acoustic signal in a vertebrate vocal network.
    1. Neuroscience

    Constructing an adult orofacial premotor atlas in Allen mouse CCF

    Jun Takatoh, Jae Hong Park ... Fan Wang
    A new three-step monosynaptic premotor tracing strategy in adult mice, together with registration to the Allen mouse common coordinate framework, uncovered precise spatial relationships of distinct orofacial premotor circuits in the brainstem.
    1. Neuroscience

    Dbx1 precursor cells are a source of inspiratory XII premotoneurons

    Ann L Revill, Nikolas C Vann ... Gregory D Funk
    Building on previous work (Wang et al., 2014), we use a combination of genetic, electrophysiology and laser ablation approaches to identify a developmentally defined population of neurons that are a significant source of clinically relevant inspiratory drive to XII motoneurons.