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    1. Cell Biology
    2. Human Biology and Medicine

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha et al.
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
    1. Developmental Biology

    YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

    Chuwen Lin et al.
    The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
    1. Neuroscience

    Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity

    Qiang Chen et al.
    Synapse-specific genetic manipulations show that distinct GABAergic inputs are differentially recruited to encode motion direction in the retina in a stimulus-dependent manner.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

    Jefferson J Doyle et al.
    Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.
    1. Neuroscience

    Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion

    Adriane G Otopalik et al.
    Reliable neuronal physiology can arise from variable and inefficient morphologies.
    1. Neuroscience

    A cellular and regulatory map of the cholinergic nervous system of C. elegans

    Laura Pereira et al.
    Analyzing a map of all cholinergic neurons in the nematode C. elegans shows how these neurons are embedded in the C. elegans connectome and reveals the regulatory factors controlling their development.
    1. Neuroscience

    Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice

    Shu-Hsien Sheu et al.
    A similar pattern of developmental synaptic refinement leads two consecutive synaptic relays to have the same organization suggesting that some general principle of neural organization is at play.
    1. Developmental Biology
    2. Neuroscience

    Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

    Hao Wu et al.
    The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.
    1. Neuroscience

    Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses

    Laura Hanson et al.
    Experimental and computational models reveal how parallel 'core' mechanisms shape direction selectivity at the dendrites of starburst amacrine cells and ganglion cells in the mouse retina.
    1. Neuroscience

    The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit

    Shruti Shankar et al.
    The cellular and molecular substrates that underlie the programmed behavioral response to a gustatory sex pheromone have been identified.