Browse the search results

Repressing the conserved pro-differentiation let-7 microRNAs through limiting Ago2 levels is critical to maintaining pluripotency in stem cells.

Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.

OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.

Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.

Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.

AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.

The various transposon families of the mammalian genome can adopt different types of repressive chromatin responses upon DNA methylation loss.

Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.

Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.

Mcm2 promotes mouse embryonic stem cells differentiation through manipulating chromatin landscapes at bivalent chromatin domains.