A panel of seven new mouse strains with chromosomal duplications is used to identify a minimal genetic region required in three copies to cause congenital heart defects typical of human Down syndrome.

The trace amine-associated receptor 1 gene has a causal role in methamphetamine intake and thermal response, and interacts with the mu-opioid receptor gene in its methamphetamine addiction-related effects.

Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.

Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.

Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.

Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.

Genetic and epigenetic editing experiments establish causal links between transposon-derived enhancers and gene regulation in mouse embryonic and extraembryonic lineages.

A genetic program controlling brain genes across the lifespan specifies a calendar of changes in cells, synapses and behavioural genes thereby timing the onset of mental illnesses which arise in young adults.

Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.

The vesicular Ca²⁺ sensor synaptotagmin-1 regulates both fast phasic and slow tonic glutamate release at ribbon synapses of rod and cone photoreceptor cells.