Five mouse models of autism show deficits in delay eyeblink conditioning, a form of split-second sensory learning that involves the cerebellum, a frequent site of disruption in autistic brains.
A realistic model of the connections between local populations of neurons in the adult mouse brain can be constructed based on just two biologically plausible rules.
A viable separation of function XRCC4 knock-in mutant mouse model recapitulates some aspects of XRCC4 deficiency in humans, notably the absence of immune deficiency.
Restoration of endogenous frataxin levels reverses neurologic and cardiac phenotypes associated with Friedreich's ataxia in adult mice even after significant motor dysfunction.
The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, whilst head direction tuning remains intact.
PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.
