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    1. Neuroscience

    Cerebellar associative sensory learning defects in five mouse autism models

    Alexander D Kloth et al.
    Five mouse models of autism show deficits in delay eyeblink conditioning, a form of split-second sensory learning that involves the cerebellum, a frequent site of disruption in autistic brains.
    1. Computational and Systems Biology
    2. Neuroscience

    A simple generative model of the mouse mesoscale connectome

    Sid Henriksen et al.
    A realistic model of the connections between local populations of neurons in the adult mouse brain can be constructed based on just two biologically plausible rules.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

    Benoit Roch et al.
    A viable separation of function XRCC4 knock-in mutant mouse model recapitulates some aspects of XRCC4 deficiency in humans, notably the absence of immune deficiency.
    1. Neuroscience

    Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia

    Vijayendran Chandran et al.
    Restoration of endogenous frataxin levels reverses neurologic and cardiac phenotypes associated with Friedreich's ataxia in adult mice even after significant motor dysfunction.
    1. Neuroscience

    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

    Barbara Commisso et al.
    The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

    Cassandra L Stowe et al.
    Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
    1. Neuroscience

    Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy

    Thomas Ridler et al.
    Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, whilst head direction tuning remains intact.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

    Minxian Qian et al.
    The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Multiple knockout mouse models reveal lincRNAs are required for life and brain development

    Martin Sauvageau et al.
    Long intergenic noncoding RNA molecules (lincRNAs) are shown to have critical roles in mammalian development and physiology in vivo.
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

    Yoko Ogawa et al.
    PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.