3,574 results found
    1. Neuroscience

    A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

    Meng Kuan Lin et al.
    A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The modular mechanism of chromocenter formation in Drosophila

    Madhav Jagannathan et al.
    Cell biological study reveals the mechanism by which multiple satellite-DNA-binding proteins cooperate to form chromocenter to encapsulate the full complement of chromosomes.
    1. Developmental Biology

    Specification of diverse cell types during early neurogenesis of the mouse cerebellum

    John W Wizeman et al.
    Single-cell RNA sequencing resolves inter- and intra-population heterogeneity, identifies rare cell types, and reconstructs specification trajectories during early neurogenesis of the mouse cerebellum.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Pyrophosphate modulates plant stress responses via SUMOylation

    M Görkem Patir-Nebioglu et al.
    In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang et al.
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young et al.
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
    1. Neuroscience

    Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation

    Marieke MB Hoekstra et al.
    The temperature-sensitive protein CIRBP contributes to the effect of sleep loss on the molecular circadian clock.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

    Evanthia Zacharioudaki et al.
    Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.
    1. Evolutionary Biology
    2. Neuroscience

    Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis

    Ian F Miller et al.
    The exceptionally large size of the human brain is the result of accelerating evolution towards larger brains in hominins, but is not the product of neocortical expansion.
    1. Cell Biology
    2. Human Biology and Medicine

    Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

    King Faisal Yambire et al.
    Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.

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