9,834 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Medicine
    2. Neuroscience

    Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors

    Joshua S Talboom, Asta Håberg ... Matthew J Huentelman
    An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.
    1. Medicine
    2. Microbiology and Infectious Disease

    Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

    A Sarah Walker, Emma Pritchard ... COVID-19 Infection Survey team
    Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.
    1. Epidemiology and Global Health
    2. Medicine

    Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

    ISARIC Clinical Characterisation Group, Matthew D Hall ... Piero L Olliaro
    Patient outcomes, and the time spent by patients during hospital admission, showed considerable variation over the first year of the COVID-19 pandemic.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates, James D Manton ... Gregory SXE Jefferis
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Ecology
    2. Plant Biology

    Unprecedented yet gradual nature of first millennium CE intercontinental crop plant dispersal revealed in ancient Negev desert refuse

    Daniel Fuks, Yoel Melamed ... Ehud Weiss
    New archaeobotanical data from Negev Highland rubbish middens demonstrate that crop diversity in the Southern Levant expanded more during the first millennium CE than in any earlier period, yet with minimal consequences for consumption and production patterns.
    1. Neuroscience

    Information flow, cell types and stereotypy in a full olfactory connectome

    Philipp Schlegel, Alexander Shakeel Bates ... Gregory S X E Jefferis
    Synaptic resolution analysis of a full olfactory connectome reveals lateralised circuits, convergence of innate and learned pathways, and shows that homologous neurons are highly stereotyped within and across brains.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments

    Alwyn Dady, Lindsay Davidson ... Kate G Storey
    Comparison of human spinal cord rosette differentiation in vitro and following transplantation into heterologous embryonic environments, reveals cell-intrinsic constraint on human differentiation pace and the importance of timely extrinsic signalling for progression through an intrinsic human neural differentiation programme.
    1. Cell Biology

    Male meiotic spindle features that efficiently segregate paired and lagging chromosomes

    Gunar Fabig, Robert Kiewisz ... Thomas Müller-Reichert
    Chromosome segregation in male spermatocytes exhibits anaphase A without shortening of autosome-associated microtubules and partitioning of an unpaired X chromosome that is initiated by an imbalance of attached kinetochore microtubules.
    1. Plant Biology

    The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation

    M Rosario Ramírez-Flores, Sergio Perez-Limon ... Ruairidh JH Sawers
    Heritable variation in the benefit maize plants receive from arbuscular mycorrhizal fungi supports the feasibility of breeding crops to optimize use of this ancient symbiosis.

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