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    1. Immunology and Inflammation

    A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

    Yan Qian, Qiannv Liu ... Pengyan Xia
    Revised
    Reviewed Preprint v2
    Updated
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    1. Immunology and Inflammation

    Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

    Pedro P Cunha, Eleanor Minogue ... Randall S Johnson
    Oxygen levels at the time of T cell activation are major determinants of function, even when T cells are subsequently expanded in high levels of oxygen.
    1. Cell Biology
    2. Neuroscience

    Glycolytic reliance promotes anabolism in photoreceptors

    Yashodhan Chinchore, Tedi Begaj ... Constance L Cepko
    Aerobic glycolysis in rod photoreceptors of adult mice is regulated by allostery and FGF signaling and is required for maintaining outer segments.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging

    Xingbo Yang, Gloria Ha, Daniel J Needleman
    Mitochondrial metabolic fluxes display a subcellular spatial gradient within a single mouse oocyte, and the fluxes are not controlled by nutrient supply or energy demand of the cell, but by the intrinsic rates of mitochondrial respiration.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    eIF3 engages with 3’-UTR termini of highly translated mRNAs

    Santi Mestre-Fos, Lucas Ferguson ... Jamie HD Cate
    The extent of human eukaryotic translation initiation factor eIF3 interaction with the 3' ends of mRNA 3' untranslated regions (3'-UTRs) correlates with the level of translation.
    1. Cell Biology

    Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

    Maxence Le Vasseur, Jonathan Friedman ... Jodi Nunnari
    OCIAD1 associates with prohibitin assemblies and regulates the proteolytic processing and stability of the catalytical Complex III subunit cytochrome c1.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner, Fabian Beier ... Arne Traulsen
    Telomere length distributions can be used to infer important properties of stem cell proliferation.
    1. Microbiology and Infectious Disease

    Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase

    Azadeh Seidi, Linden S Muellner-Wong ... Giel G van Dooren
    The proteins found in the mitochondria of apicomplexan parasites, including key proteins involved in energy generation, are very different from mitochondrial proteins of the animals these parasites infect.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose, Nudrat Noor ... Simon R Myers
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Cell Biology

    QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

    Virginia Guarani, Elizabeth M McNeill ... J Wade Harper
    A comprehensive analysis of the human MICOS complex has identified a novel subunit called QIL1 that is required for cristae junction formation in human cells and Drosophila, through its role in the assembly of the MICOS complex.