132 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

    Lu Yu et al.
    Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Immune Response: An ambulance for retinol

    Stephanie C Ganal, Andrew J MacPherson
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    1. Developmental Biology
    2. Immunology and Inflammation

    Symbiosis: Protection from within

    Florent Masson, Bruno Lemaitre
    The development of the tsetse fly immune system relies on a cue from an endosymbiotic bacterium called Wigglesworthia.
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    1. Microbiology and Infectious Disease
    2. Ecology

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IRF4 haploinsufficiency in a family with Whipple’s disease

    Antoine Guérin et al.
    Autosomal dominant IRF4 deficiency is the first genetic etiology of Whipple's disease, a very rare chronic condition following a rather common infection by Tropheryma whipplei.
    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet et al.
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Immunology and Inflammation

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al.
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    1. Developmental Biology

    SOX2 regulates acinar cell development in the salivary gland

    Elaine Emmerson et al.
    Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Cancer Biology

    Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

    Andrea Strakova et al.
    Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and rearranged its mitochondrial DNA along the way.

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