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A new technique called fastFISH enables nearly real-time and stoichiometric detection of nascent RNA and the tracking of individual stages of transcription at the level of single-molecules.

An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.

Slow conformational changes after drug binding rationalize selectivity, affinity and long on-target residence time for kinase inhibitors.

Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.

Arc-shaped PFO oligomers consisting of at least four subunits can insert into the membrane in a kinetically controlled process opening a transmembrane pore, whereby post-insertion growth may ultimately lead to formation of a complete ring.

A multi-step process of helicase activation sensitizes replication initiation to the extent of replicative helicase phosphorylation.

A model of pathogen co-evolving with host population continuously acquiring immunity is used to identify evolutionary parameters allowing pathogen population to persist without going extinct or splitting into independent lineages.

The diguanylate cyclase activity of SiaD is activated by its binding partner SiaC thourgh a dynamic mechanism of promoting the formation of active SiaD dimers.

Excitability gradients in heart tissue, imposed by structured sub-threshold optogenetic stimulation, induce drift and termination of spiral waves, thus providing an explanation for successful optogenetic defibrillation in small animal hearts.

Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.