840 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Towards deep learning with segregated dendrites

    Jordan Guerguiev et al.
    A multi-compartment spiking neural network model demonstrates that biologically feasible deep learning can be achieved if sensory inputs and higher-order feedback are received by different dendritic compartments.
    1. Neuroscience

    Brian 2, an intuitive and efficient neural simulator

    Marcel Stimberg et al.
    Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
    1. Neuroscience

    Encoding and control of orientation to airflow by a set of Drosophila fan-shaped body neurons

    Timothy A Currier et al.
    Electrophysiology identifies a population of fan-shaped body neurons that encode airflow in two directions relative to the fly midline and whose silencing disrupts proper orientation to airflow.
    1. Cell Biology
    2. Computational and Systems Biology

    Removing physiological motion from intravital and clinical functional imaging data

    Sean C Warren et al.
    Image-based motion correction enables the use of fluorescence lifetime and other functional imaging modalities in an intravital and clinical context in the presence of physiological motion.
    1. Neuroscience

    Synaptic input sequence discrimination on behavioral timescales mediated by reaction-diffusion chemistry in dendrites

    Upinder Singh Bhalla
    The powerful computational operation of sequence recognition on behavioral timescales of approximately 1 s may emerge from synaptic activity-triggered build-up of biochemical waves in short 20 micron zones on dendrites.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué et al.
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
    1. Cell Biology
    2. Computational and Systems Biology

    Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

    Alfonso Bolado-Carrancio et al.
    Different RhoA and Rac1 dynamics at the cell front and rear are coordinated through periodic GTPase waves, which define the minimal autonomous biochemical machinery necessary and sufficient for cell migration.
    1. Neuroscience

    Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions

    Vladislav Sekulić, Frances K Skinner
    The contribution of biophysical ion channels to neuron function can be predicted by taking advantage of an ongoing dialogue between model and experiment.
    1. Cancer Biology

    A generalized theory of age-dependent carcinogenesis

    Andrii Rozhok, James DeGregori
    The multi-stage model of carcinogenesis requires the incorporation of aging-dependent somatic selection and life history-dependent evolution of species-specific tumor suppressor mechanisms in order to generalize carcinogenesis across tissues and species.
    1. Neuroscience

    Noninvasive quantification of axon radii using diffusion MRI

    Jelle Veraart et al.
    Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.

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