90 results found
    1. Developmental Biology
    2. Genetics and Genomics

    The rosetteless gene controls development in the choanoflagellate S. rosetta

    Tera C Levin, Allison J Greaney ... Nicole King
    The establishment of forward genetics in S. rosetta reveals the first gene known to be required for choanoflagellate multicellular development.
    1. Neuroscience

    A multicellular rosette-mediated collective dendrite extension

    Li Fan, Ismar Kovacevic ... Zhirong Bao
    Migrating skin carries the amphid rosette vertex anteriorly to extrude and position dendrites.
    1. Developmental Biology
    2. Genetics and Genomics

    Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta

    David S Booth, Nicole King
    Genome editing in the choanoflagellate Salpingoeca rosetta opens newfound possibilities to functionally probe choanoflagellate genes that may illuminate the origin of their closest relatives, the animals.
    1. Cell Biology

    A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

    Rosanna A Alegado, Laura W Brown ... Nicole King
    The development of colonies of cells in choanoflagellates, water-dwelling organisms that feed on bacteria, is triggered by the presence of very low concentrations of a lipid molecule produced by certain types of bacteria.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicted glycosyltransferases promote development and prevent spurious cell clumping in the choanoflagellate S. rosetta

    Laura A Wetzel, Tera C Levin ... Nicole King
    A genetic screen reveals that two predicted glycosyltransferases promote rosette development and prevent cell clumping in one of the closest living relatives of animals, the choanoflagellate S. rosetta.
    1. Plant Biology

    Combining growth-promoting genes leads to positive epistasis in Arabidopsis thaliana

    Hannes Vanhaeren, Nathalie Gonzalez ... Dirk Inzé
    Pairwise combinations of growth-promoting genes regulating distinct cellular mechanisms lead to synergistic effects on leaf growth, and hence greatly increased leaf size.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Engineering induction of singular neural rosette emergence within hPSC-derived tissues

    Gavin T Knight, Brady F Lundin ... Randolph Scott Ashton
    A bioengineering approach identifies tissue morphology as an effective variable for controlling the inception of neural organoid morphogenesis via induction of a biomimetic, singular neural rosette tissue cytoarchitecture.
    1. Cell Biology
    2. Evolutionary Biology

    Evolution of an ancient protein function involved in organized multicellularity in animals

    Douglas P Anderson, Dustin S Whitney ... Kenneth E Prehoda
    Experimentally reconstructing the evolution of the molecular complex that animals use to orient the mitotic spindle establishes a simple genetic and physical mechanism for the emergence of a function essential for multicellularity.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė, Ren Yi ... Tatjana Piotrowski
    Cell adhesion regulates organ size in the zebrafish lateral line system.

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