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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Pathogen Evolution: Exploring accidental virulence

    Daniel FQ Smith
    Experimentally evolving yeast to adhere better to plastic led to adaptations that increased their ability to cause an infection.
    Version of Record
    Insight
    1. Evolutionary Biology

    Evolutionary adaptation to juvenile malnutrition impacts adult metabolism and impairs adult fitness in Drosophila

    Berra Erkosar, Cindy Dupuis ... Tadeusz J Kawecki
    Juvenile and adult metabolism are constrained from evolving independently from each other even in a species that lacks developmental continuity between juvenile and adult organs.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

    Vivian Chen, Milo S Johnson ... Gavin Sherlock
    Pleiotropy of adaptive clones isolated from diverse experimental environment.
    1. Evolutionary Biology

    Evolutionary consequences of nascent multicellular life cycles

    Jennifer T Pentz, Kathryn MacGillivray ... William C Ratcliff
    Clonal development, but not aggregation, promotes the transition of Darwinian individuality from cells to groups, emphasizing the fundamental role of initial multicellular life cycles in the evolution of multicellularity.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K

    Matthew T Parker, Sebastian M Fica ... Gordon G Simpson
    A computational approach examines the roles of splicing factors and their association with evolutionary change in splicing.
    1. Plant Biology

    Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

    Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala
    Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.
    1. Developmental Biology
    2. Physics of Living Systems

    Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis

    Krishnan S Iyer, Chaitra Prabhakara ... Madan Rao
    An information theoretic and systems biology approach shows that cellular compartmentalisation and receptor promiscuity can facilitate the accurate and robust inference of position from noisy morphogen profiles, verified by experiments in Drosophila wing imaginal disc.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Structural Biology and Molecular Biophysics

    Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

    Justine M Pinskey, Adhya Lagisetty ... Daniela Nicastro
    Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.
    1. Cell Biology
    2. Developmental Biology

    Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling

    Woong Y Hwang, Valentyna Kostiuk ... Mustafa K Khokha
    β-catenin, a key effector of the Wnt signaling pathway, is transported into the nucleus via a direct interaction between its PY-NLS and TNPO1 offering new potential targets for cancer therapeutics.