CDKG1 is a D-cyclin dependent retinoblastoma related protein kinase whose abundance scales with cell size and controls cell division cycle number during multiple fission.
Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.
Juvenile and adult metabolism are constrained from evolving independently from each other even in a species that lacks developmental continuity between juvenile and adult organs.
An information theoretic and systems biology approach shows that cellular compartmentalisation and receptor promiscuity can facilitate the accurate and robust inference of position from noisy morphogen profiles, verified by experiments in Drosophila wing imaginal disc.
Olivier Cochet-Escartin, Mete Demircigil ... Jean-Paul Rieu
Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
Arielle Woznica, Ashwani Kumar ... Julie K Pfeiffer
Developing Monosiga brevicollis as a model to study choanoflagellate immune responses reveals that the innate immune protein STING mediates responses to cyclic dinucleotides in choanoflagellates, providing insight into the evolution of STING signaling on the animal stem lineage.
The investigation of neuroimmunology in non-model organisms is critical to diversify the field and identify primordial principles that govern neuroimmune communication across taxa.
Shelly TH McClatchey, Zheng Wang ... David R Sherwood
A Notch-mediated signaling pathway upregulates a Sec14-GOLD phosphopholipid binding protein that promotes a morphogenetic process important in tissue remodeling and renewal.
