The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.

Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.

The anaphase promoting complex (APC) has an essential role in ubiquitin-mediated proteolysis in the disassembly of cilia.

In cell types that acquire planar cell polarity, the protein Flattop regulates basal body docking and positioning.

Planarians provide evidence for a common evolutionary origin of vertebrate and invertebrate excretory systems and provide a novel experimental model to study human kidney diseases.

Mutations in KIAA0586 (TALPID3) cause a severe ciliopathy called Joubert syndrome that affects organ, cell and centrosome polarity.

Direct patch clamp of ependymal motile cilia reveals that voltage-gated calcium channels in the cell body dominate their electrical and calcium signaling properties.

At optimal concentrations, the ciliary inhibitor Cp110 promotes ciliogenesis by localization to previously uncharacterized sites at the basal body, where it recruits ciliary adhesion complexes that mediate basal body interaction with F-actin networks.

Vertebrate early ectoderm displays planar polarity manifested by a fluorescent sensor and this polarity can be instructed by Wnt ligands.

Building on previous work (Dye et al., 2015) showing that pluripotent stem cell derived lung organoids were immature/fetal, the current study shows that in vivo transplantation leads to mature tissue, reminiscent of adult airways.