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    1. Genetics and Genomics

    Neuroendocrinology of the lung revealed by single-cell RNA sequencing

    Christin S Kuo, Spyros Darmanis ... Mark A Krasnow
    Single-cell transcriptomic profiling and systematic analysis of pulmonary neuroendocrine cells identifies over 40 hormones and neuropeptides expressed in myriad combinations, and predicts their targets in mouse and human lung, revealing extraordinary sensory and signaling diversity and potential physiological functions.
    1. Developmental Biology

    Chloride channels regulate differentiation and barrier functions of the mammalian airway

    Mu He, Bing Wu ... Lily Yeh Jan
    The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.
    1. Immunology and Inflammation

    Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

    Marie Alexandre, Romain Marlin ... Rodolphe Thiébaut
    A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to define mechanistic correlates of protection.
    1. Cell Biology
    2. Developmental Biology

    Ciliary length regulation by intraflagellar transport in zebrafish

    Yi Sun, Zhe Chen ... Chengtian Zhao
    The speed of intraflagellar transport, influenced by particle size, shows a positive correlation with ciliary length in zebrafish.
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    1. Cell Biology

    Intraflagellar transport drives flagellar surface motility

    Sheng Min Shih, Benjamin D Engel ... Ahmet Yildiz
    The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.
    1. Developmental Biology

    Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2

    Xiaoliang Liu, Ting Yu ... Chi Liu
    During nephron regeneration, renal interstitial cells promote the proliferation of renal progenitor cells by secreting PGE2, thus forming the microenvironment of renal progenitor cells.
    1. Cell Biology

    A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells

    Ewelina Betleja, Rashmi Nanjundappa ... Moe R Mahjoub
    Cells have evolved a mechanism that actively regulates centriole maturation during quiescence.
    1. Developmental Biology

    Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

    Merve Bilgic, Quan Wu ... Fumio Matsuzaki
    Single-cell transcriptome analyses during cortical brain development in ferrets and its comparison with public human datasets reveal that there are common progenitors and lineages among gyrencephalic mammalian brain development.
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat, Mette Handberg-Thorsager ... Guillaume Balavoine
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Developmental Biology
    2. Physics of Living Systems

    Theoretical tool bridging cell polarities with development of robust morphologies

    Silas Boye Nissen, Steven Rønhild ... Kim Sneppen
    Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.