54 results found
    1. Microbiology and Infectious Disease

    Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis

    Vegard Eldholm et al.
    HIV co-infection does not affect Mycobacterium tuberculosis mutation rates and does not drive the emergence of antimicrobial resistance within patients in the largest outbreak of multidrug-resistant tuberculosis in Latin America to date.
    1. Epidemiology and Global Health

    Epidemiology and burden of multidrug-resistant bacterial infection in a developing country

    Cherry Lim et al.
    The burden of antimicrobial resistance in Thailand is deteriorating over time, and 19,122 deaths in the country in 2010 were excess deaths caused by multidrug-resistant bacterial infection.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

    James E Gomez et al.
    Mutations in several components of a bacterial ribosome are shown to broadly decrease antibiotic and stress sensitivity, and readily accessible reversion mutations allow these ribosomal mutations to serve as stepping stones to high level antibiotic resistance.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB

    Yasuhiro Matsunaga et al.
    High-performance computing simulations reveal how two remote sites in the multidrug transporter AcrB work together for drug extrusion using the proton-motive force.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

    Thomas Eicher et al.
    A transport mechanism is uncovered in the major drug-efflux system in E. coli involving two remote alternating-access conformational cycles, which could provide the basis for the development of allosteric inhibitors against multidrug resistance.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Point of View: Tuberculosis innovations mean little if they cannot save lives

    Madhukar Pai, Jennifer Furin
    Ending the TB epidemic requires scaling up access to new TB tools so that they can benefit the patients in low- and middle-income countries that need them the most.
    1. Epidemiology and Global Health

    Tuberculosis: Fighting an old disease with next-generation sequencing

    Anzaan Dippenaar, Robin M Warren
    Insight
    Available as:
    • HTML
    • PDF
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

    Robert M Cooper et al.
    Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.
    1. Microbiology and Infectious Disease

    Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

    Toon Swings et al.
    Population mutation rates are highly flexible and evolvable under extreme stress conditions, matching changes in selective pressure to avoid extinction of the entire population.
    1. Developmental Biology

    Patched1 and Patched2 inhibit Smoothened non-cell autonomously

    Brock Roberts et al.
    Ptch1/2 can lower the sensitivity of Smo to activation by Shh via the secretion of a sterol precursor.

Refine your results by:

Type
Research categories