310 results found
    1. Neuroscience

    Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

    Xiaohui Yan et al.
    Convergent structural and functional brain deficits associated with dyslexia were found in left superior temporal gyrus across languages, however, language-specific deficits were also identified.
    1. Neuroscience

    Lying in a 3T MRI scanner induces neglect-like spatial attention bias

    Axel Lindner et al.
    Exposing subjects to the magnetic field of an MRI scanner stimulates the vestibular organ and thereby induces a horizontal bias of spatial orienting and exploration similar to that seen in stroke patients with spatial neglect.
    1. Neuroscience

    Hippocampal replay of experience at real-world speeds

    Eric L Denovellis et al.
    A new state space decoder revealed that most hippocampal sharp-wave ripples contain coherent spatial content, and that this 'replay' typically progresses at speeds similar to those seen during actual experiences.
    1. Medicine

    Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

    Mieradilijiang Abudupataer et al.
    An aorta smooth muscle-on-a-chip model indicated that NOTCH1 insufficiency in HAoSMCs induced phenotypic switching from a contractile to a synthetic phenotype accompanied by an impairment of mitochondrial fusion, implying its potential role as a therapeutic target for BAV-TAA.
    1. Neuroscience

    The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

    Casey Paquola et al.
    The BigBrainWarp toolbox facilitates integration of 3D human brain histology with neuroimaging, helping neuroscientists to utilise cytoarchitectural information in conjunction with in vivo imaging.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

    Michele Felletti et al.
    Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
    1. Genetics and Genomics
    2. Neuroscience

    Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization

    Brian R Lee et al.
    High-quality, multimodal, electrophysiological, morphological, and transcriptomic data collection from a single cell using a refined Patch-seq protocol.
    1. Microbiology and Infectious Disease

    Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

    Thomas P Burke et al.
    Type I interferon and interferon-γ signaling redundantly protects mice from the tick-borne pathogen Rickettsia parkeri in the skin, and interferon receptor-deficient mice are a tractable model for investigating rickettsiosis.
    1. Neuroscience

    The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

    Yunuen Moreno-Lopez et al.
    While the corticospinal tract is often considered exclusively as a motor path, a combination of intersectional viral strategy and in vivo electrophysiology reveals that, in the mouse lumbar cord, its main role is the modulation of sensory inputs.
    1. Developmental Biology
    2. Neuroscience

    Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

    Liyun Zhang et al.
    Using a cross-species phenotypic drug discovery pipeline, compounds promoting rod photoreceptor survival in zebrafish and mouse models of retinitis pigmentosa were identified, evidence of additive effects of paired compounds and inhibition of PARP-dependent cell death suggest novel therapeutic strategies.

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