6,780 results found
    1. Structural Biology and Molecular Biophysics

    Automated cryo-EM structure refinement using correlation-driven molecular dynamics

    Maxim Igaev et al.
    Correlation-driven molecular dynamics provides a fully automated and human-bias-free framework for quantitative interpretation of modern cryo-electron microscopy data.
    1. Computational and Systems Biology

    Selecting the most appropriate time points to profile in high-throughput studies

    Michael Kleyman et al.
    The Time Point Selection (or TPS) method is a general protocol for determining sampling rates for high throughout time series biological studies, that is efficient, cheap, scalable and works well for several different types of molecular data.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf et al.
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller et al.
    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.
    1. Evolutionary Biology

    Multifactorial processes underlie parallel opsin loss in neotropical bats

    Alexa Sadier et al.
    Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
    1. Neuroscience

    Cognitive regulation alters social and dietary choice by changing attribute representations in domain-general and domain-specific brain circuits

    Anita Tusche, Cendri A Hutcherson
    Regulatory success operates by goal-consistent increases and decreases of distinct attribute representations in generic neural hubs and in domain-specific brain regions, explaining when and why regulatory success generalizes across domains and contexts.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Computational and Systems Biology
    2. Neuroscience

    Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

    William Hedley Thompson et al.
    Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
    1. Neuroscience
    Scatter plot

    Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript

    Tamar R Makin, Jean-Jacques Orban de Xivry
    What can authors and reviewers do to keep common statistical mistakes out of the literature?
    1. Medicine

    Research: Adequate statistical power in clinical trials is associated with the combination of a male first author and a female last author

    Willem M Otte et al.
    An analysis of 31,873 clinical trials shows that adequate statistical power was most often present in trials with a male first author and a female last author.

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