Imaging mass cytometry simultaneously lights up distinct immune cells in the brain.

Computational-driven, imaging-based topological profiles of neurodegeneration differ substantially in different neurodegenerative conditions, suggesting distinct modes of dependence of the pathological spread on the underlying connectivity.

Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.

Antigen-specific control of CD4+ T cell trans-migration by brain endothelial cells via presentation of CNS-derived antigens in MHC-II molecules.

Regeneration of oligodendrocytes in the cerebral cortex results in reorganization of the pattern of myelination, potentially impacting information processing within cortical networks in diseases such as multiple sclerosis.

A novel EAE model featuring cortical lesions and an autoimmune heterogeneity, two key parameters missing in the classical model, allows for insights in disease pathogenesis.

A link between chronic stress and organ dysfunction is explained by the gateway reflex, in which brain micro-inflammation at specific vessels establishes a new neural pathway to induce fatal organ failure particularly in gastrointestine and heart.

Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.

Ultrastructural and loss-of-function experiments show that oligodendrocyte-encoded Kir4.1 is located near active axonal structures, including within myelin inner tongue, and has critical functions to promote axonal activity and preserve integrity.