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    1. Microbiology and Infectious Disease

    High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

    Claudia A Vera-Arias, Aurel Holzschuh ... Cristian Koepfli
    A novel high-throughput method for Plasmodium falciparum genotyping will enable malaria control programs to make informed decisions about the best tool to use for the diagnosis of malaria.
    1. Cell Biology
    2. Medicine

    Cellular features of localized microenvironments in human meniscal degeneration: a single-cell transcriptomic study

    Weili Fu, Sijie Chen ... Xuegong Zhang
    A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
    1. Neuroscience

    Identification of an early subset of cerebellar nuclei neurons in mice

    Maryam Rahimi-Balaei, Shayan Amiri ... Hassan Marzban
    A distinct subset of cerebellar nuclei neurons originates from a previously unrecognized germinal zone within the cerebellar primordium, independent of Atoh1 influence, highlighting new cellular origins in cerebellar development.
    1. Neuroscience

    A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

    Kristina D Micheva, Dylan Wolman ... Davi D Bock
    Parvalbumin-positive inhibitory neurons in the cortex have insulating myelin sheathes, despite forming only short-range connections.
    1. Neuroscience

    Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

    Michael O Breckwoldt, Julia Bode ... Björn Tews
    Correlated magnetic resonance imaging and ultramicroscopy resolves macro- and microvasculature in glioma models and allows treatment monitoring of antiangiogenic therapy.
    1. Neuroscience

    BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior

    Kristen R Maynard, John W Hobbs ... Keri Martinowich
    Brain-derived neurotrophic factor signaling plays a causal role in female-typical social behavior and modulates oxytocin neuron gene expression.
    1. Neuroscience

    Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs

    Didier De Saint Jan
    Muscarinic excitation of a previously ignored subtype of periglomerular interneuron in the olfactory bulb by endogenous synaptic release of acetylcholine.
    1. Immunology and Inflammation

    Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

    Valeria Ramaglia, Salma Sheikh-Mohamed ... Jennifer L Gommerman
    Imaging mass cytometry simultaneously lights up distinct immune cells in the brain.
    1. Cell Biology
    2. Immunology and Inflammation

    Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10

    Ana J Caetano, Yushi Redhead ... Paul T Sharpe
    Integrated single-cell and spatial genomics provides the first molecular map of the human oral mucosa and reveals a novel pro-inflammatory fibroblast involved in disease progression.
    1. Neuroscience

    Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids

    Xin-Yan Zhang, Yan-Nong Dou ... Yan-Gang Sun
    Exogenous opioid analgesia is mediated by MORs expressed in glutamatergic neurons, whereas endogenous opioid analgesia is mediated by MORs expressed in GABAergic neurons.