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Genome-wide analyses reveal how tumor-associated mutations of the Fbw7 ubiquitin ligase impact oncogenic transcription factors and gene expression.

Pre-RC component Cdc6 is primed for origin licensing by phosphatases and Cdk1 inhibitor.

Disposal of ciliary proteins via ectosomes budding from cilia tip or cilia base acts as a safeguard mechanism when cilia trafficking functions are impaired.

Network symmetry represents a new vantage point for dissecting complex information processing characteristics in multisite modification, and the breaking of symmetry can confer ordering of modification and absolute concentration robustness.

CHMP7 is phosphorylated by CDK1 upon mitotic entry, preventing interaction with LEM2 and inappropriate assembly during mitotic exit.

An anchored phosphatase-deacetylase complex participates in primary cilia development.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

Development of a real-time SnRK2 kinase FRET reporter reveals rapid SnRK2 activation by ABA, but not by Methyl-Jasmonate or elevated CO2, while directly demonstrating basal SnRK2 activity in guard cells.

UNC119 complexes the microtubule binding CRMP to the cortical Ankyrin to immobilize the microtubule cytoskeleton in Caenorhabditis elegans neurons.

A novel dynamic charge-charge interaction between B56 and a subset of PP2A-B56 substrates is essential for substrate specificity, dephosphorylation and, for KIF4A, binding condensin I.