76 results found
    1. Computational and Systems Biology

    Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET

    Johannes M Keegstra, Keita Kamino ... Thomas S Shimizu
    Noise in a signaling network comprising thousands of molecules shapes diversity across cell populations and generates giant temporal fluctuations at the single-cell level.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic consequences of hybridization

    Benjamin M Moran, Cheyenne Payne ... Molly Schumer
    A synthesis of recent hybridization literature reveals emerging patterns in the evolution of genomes after hybridization, processes proposed to explain those patterns, and important open questions to direct future hybrid genomics research.
    1. Computational and Systems Biology

    Emergence and propagation of epistasis in metabolic networks

    Sergey Kryazhimskiy
    Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
    1. Neuroscience

    Selective increases in inter-individual variability in response to environmental enrichment in female mice

    Julia C Körholz, Sara Zocher ... Gerd Kempermann
    The classical experimental paradigm of "enriched environments" is repositioned as a tool to address the question of how behavioral activity and the environment contribute to specific differences between individuals.
    1. Evolutionary Biology
    2. Plant Biology

    Environment as a limiting factor of the historical global spread of mungbean

    Pei-Wen Ong, Ya-Ping Lin ... Cheng-Ruei Lee
    After domestication, the cultivation range expansion of crops was not solely dictated by human activity but instead constrained by climatic factors, which in turn resulted in distinct phenotypic characteristics of locally adaptive landraces.
    1. Cell Biology
    2. Developmental Biology

    bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring

    Vítor Trovisco, Katsiaryna Belaya ... Daniel St Johnston
    The localisation of bicoid mRNA depends on its microtubule-independent anchoring at the oocyte anterior.
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

    Stephan Kamrad, María Rodríguez-López ... Jürg Bähler
    An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
    1. Neuroscience

    Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies

    Felipe Martelli, Natalia H Hernandes ... Hugo J Bellen
    The organic insecticide spinosad severely impacts metabolism, the cell biology, and the visual system of the model insect Drosophila, suggesting that it poses a threat to other non-pest insect exposed to it in the field.
    1. Neuroscience

    A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex

    Vera Valakh, Derek Wise ... Sacha B Nelson
    For the first time, the strength of homeostatic plasticity has been shown to be negatively regulated and the transcription factors responsible for this regulation have been identified.

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