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    1. Genetics and Genomics

    Genomic regions controlling shape variation in the first upper molar of the house mouse

    Luisa F Pallares, Ronan Ledevin ... Sabrina Renaud
    An association mapping in wild mice revealed the first candidate loci for within-population molar shape variation and the phenotypic impact of such candidate loci was quantified and validated.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer, Christian Scheeder ... Michael Boutros
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetics of trans-regulatory variation in gene expression

    Frank Wolfgang Albert, Joshua S Bloom ... Leonid Kruglyak
    A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Global epistasis emerges from a generic model of a complex trait

    Gautam Reddy, Michael M Desai
    Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.
    1. Genetics and Genomics
    2. Neuroscience

    Population clustering of structural brain aging and its association with brain development

    Haojing Duan, Runye Shi ... Jianfeng Feng
    Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.
    1. Genetics and Genomics

    Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history

    Dilan SR Patiranage, Elodie Rey ... Christian Jung
    A new insight into quinoa diversity enables sequence-based breeding and functional genomics.
    1. Developmental Biology
    2. Neuroscience

    Cadherins regulate nuclear topography and function of developing ocular motor circuitry

    Athene Knüfer, Giovanni Diana ... Sarah Guthrie
    Cadherin-dependent cell adhesion controls the contralateral migration and clustering of ocular motor subpopulations and is required for the development of functional eye movements driven by those neurons.
    1. Computational and Systems Biology

    Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

    Zhenghao Chen, Anil Raj ... Adam Freund
    A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    Variable prediction accuracy of polygenic scores within an ancestry group

    Hakhamanesh Mostafavi, Arbel Harpak ... Molly Przeworski
    The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.