89 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death

    Mai P Tran et al.
    Evolutionary loss of foot muscle in a bipedal rodent shares similarities with skeletal muscle atrophy, which is typically considered a pathological response to injury or disease.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

    Allison M Owen et al.
    Sepsis-induced long-term muscle weakness was reproduced using a refined murine model, which was accompanied by mitochondrial dysfunction in the absence of sustained atrophy, suggesting the promise of mitochondria-targeted post-sepsis therapies.
    1. Cell Biology
    2. Human Biology and Medicine

    Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

    Yannick von Grabowiecki et al.
    Atrophic muscles of patients and animal models developing amyotrophic lateral sclerosis show an upregulation of TAp63 that stimulates the expression of a pro-atrophic ubiquitin ligase.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua et al.
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Developmental Biology

    Abelson tyrosine-protein kinase 2 regulates myoblast proliferation and controls muscle fiber length

    Jennifer K Lee et al.
    Abl2 regulates myoblast proliferation, thereby controlling the size of the pool of myoblasts available for fusion, providing insight into mechanisms that control myofiber length and signaling between muscle and tendon.
    1. Neuroscience

    Axon Growth: How to survive a nerve-wracking journey

    Andrea Yung, Lisa V Goodrich
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    1. Cell Biology

    Retinoblastoma Protein: Disruptive influence

    Giulio Cossu et al.
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    1. Neuroscience

    Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline

    Stephanie L Leal et al.
    Cognitively normal older adults show a positive relationship between neural activity during memory encoding and brain β-amyloid deposition rate over the subsequent 3-4 years, supporting preclinical data that associates neural activity with β-amyloid deposition.
    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu et al.
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.

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