1,134 results found
    1. Neuroscience

    An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

    Steven R Sando et al.
    By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

    Cameron Hill et al.
    The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.
    1. Cell Biology
    2. Physics of Living Systems

    Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

    Yong Li et al.
    Elastic forces generated by the giant protein titin define both passive and active tension of skeletal muscle fibers and protect the sarcomeric myosin filaments from severe disruption during contraction.
    1. Neuroscience

    A circuit mechanism for the propagation of waves of muscle contraction in Drosophila

    Akira Fushiki et al.
    Coordinated activation and deactivation of inhibitory neurons triggers sequential muscle contractions that enable fruit fly larvae to propel themselves backwards and forwards.
    1. Developmental Biology

    Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

    Joana Esteves de Lima et al.
    A novel mechanism links mechanical signals with the molecular YAP and NOTCH signals operating during developmental myogenesis.
    1. Stem Cells and Regenerative Medicine

    Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs

    Lauran Madden et al.
    A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.
    1. Ecology
    2. Neuroscience

    Select forelimb muscles have evolved superfast contractile speed to support acrobatic social displays

    Matthew J Fuxjager et al.
    In situ measurements of muscular twitch speed reveal one of the fastest vertebrate limb muscles on record, which evolved in association with extravagant courtship displays that include rapid limb movements.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates

    Andrew F Mead et al.
    Vertebrate superfast muscles employ similar excitation–contraction strategies but distinct myosin heavy chain genes to allow superfast performance, revealing a maximum speed that cannot be overcome without sacrificing neural control.
    1. Cell Biology

    ATP activation of peritubular cells drives testicular sperm transport

    David Fleck et al.
    Purinergic signaling controls mammalian sperm transport.
    1. Neuroscience

    Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

    Luis Alarcon-Martinez et al.
    Pericytes surrounding capillaries in the retina contain α-smooth muscle actin, demonstrating that pericytes have the necessary molecular machinery to change capillary diameter during neurovascular coupling.

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