135 results found
    1. Physics of Living Systems

    Energetic and physical limitations on the breaching performance of large whales

    Paolo S Segre et al.
    Muscle power-generating capabilities, and not energetic limitations, limit the breaching abilities of the largest whales.
    1. Epidemiology and Global Health

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien et al.
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Medicine

    Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Lorenzo Alamo et al.
    Mapping the locations of hypertrophic cardiomyopathy gene variants onto the three-dimensional structures of contractile proteins revealed that these disrupt protein interactions are critical for normal cardiac relaxation and efficient energy usage.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila

    Shouqiang Cheng et al.
    Fly protein families Dprs and DIPs can create a multitude of complementary interfaces for homo- and heterophilic adhesion complexes, resulting in instructive roles for connectivity in the motor neuron circuitry.
    1. Structural Biology and Molecular Biophysics

    Structure-based membrane dome mechanism for Piezo mechanosensitivity

    Yusong R Guo, Roderick MacKinnon
    Mechanosensitive Piezo channel induces local membrane curvature to mediate mechanical gating.
    1. Evolutionary Biology

    Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertility

    Jonathan Stieglitz et al.
    High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.
    1. Neuroscience

    Absent phasing of respiratory and locomotor rhythms in running mice

    Coralie Hérent et al.
    When mice run, their breathing frequency increases but breaths are not temporally synchronized to strides at any speed or gait.
    1. Neuroscience

    Vocal and locomotor coordination develops in association with the autonomic nervous system

    Morgan L Gustison et al.
    Marmoset monkeys develop their vocal behavior prior to their postural and locomotor skills, but the coordination of these two motor systems emerges gradually via changes in arousal level.
    1. Cell Biology

    QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease

    Virginia Guarani et al.
    Building on previous work (Guarani et al., 2015), MICOS (mitochondrial contact site) assembly and cristae junction formation are shown to have a critical role in human health.

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