2,137 results found
    1. Developmental Biology

    Intrinsic control of muscle attachment sites matching

    Alexandre Carayon et al.
    Making a link between deletion of transcription cis-regulatory elements by CrispR/Cas9, obtention of mutants with single muscle morphology defects and their impact on locomotion.
    1. Developmental Biology

    Genetic dissection of the Transcription Factor code controlling serial specification of muscle identities in Drosophila

    Laurence Dubois et al.
    Lineage-specific regulatory loops involving evolutionarily conserved myogenic Transcription Factors control muscle identity specification in Drosophila.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly

    Arkadi Shwartz et al.
    Actin is incorporated into the thin-filament arrays of skeletal muscle sarcomeres in discrete steps, and Fhos, the Drosophila homolog of FHOD-family formins, is an essential player in the process.
    1. Developmental Biology

    SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity

    Sonia Alonso-Martin et al.
    A set of ex vivo and in vivo experiments, including genetic ablation and regeneration studies, identify a key regulatory function of SOXF factors in muscle stem cells in mice.
    1. Cell Biology

    Potassium dependent rescue of a myopathy with core-like structures in mouse

    M Gartz Hanson et al.
    A mouse model of human muscle myopathy is used to provide mechanistic insight, identify possible biomarkers of disease, and suggest possible therapeutic strategies to alleviate muscle weakness.
    1. Developmental Biology

    Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

    M Lucila Scimone et al.
    Single-cell RNA sequencing identifies an adult regional gene expression map in planarian muscle that includes two FGFRL-Wnt circuits controlling head and trunk tissue pattern.
    1. Medicine

    Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

    Jonathan R Volpatti et al.
    A multi-species chemical screening platform reveals a conserved role for p38 inhibition in modulating ryanodine receptor-related phenotypes and is adaptable to a range of neuromuscular disorders.
    1. Stem Cells and Regenerative Medicine

    Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

    Matthew Gemberling et al.
    Neuregulin1 is induced upon cardiac injury in adult zebrafish, and is sufficient to drive massive proliferative growth of the heart.
    1. Immunology and Inflammation

    Identification of potential biomarkers of vaccine inflammation in mice

    Paul F McKay et al.
    Molecular biosignatures that identify an inflammatory and potentially adverse reaction to vaccination have been defined in mice, a critical gatekeeper for progression of novel vaccine candidates into humans.
    1. Chromosomes and Gene Expression

    NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

    Amy E Campbell et al.
    CRISPR/Cas9 engineered locus-specific proteomics leads to the identification of NuRD, CAF-1, and MBD3L2 as regulators of the early embryonic transcription factor DUX4.

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