A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.

Genetic architecture of muscle secreted protein functions are dominated by sex.

A clock gene expressed in skeletal muscle plays a bigger role in regulating sleep than it does in the brain.

A new tool enables electrophysiological isolation of input-specific neurotransmission in a powerful model glutamatergic circuit.

A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.

Skeletal muscle performance sets the course of rapid speciation by defining the evolutionary trajectory of reproductive behavior.

Coordinate control of lysosomal v-ATPase subunits and biogenesis factor TFEB by miR-1 identifies a key regulatory axis with strong links to age-related proteotoxic disease.

Genetically altering the size of the molecular spring element in the giant protein titin established that titin determines the stiffness of skeletal muscle and the number of sarcomeres in series.

A cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling pathway in the fruitfly Drosophila melanogaster.

A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.