1,414 results found
    1. Developmental Biology

    Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

    Joscha Griger et al.
    The stem cells of the postnatal muscle allow postnatal muscle growth and repair and withdraw from the cell cycle when the tyrosine phosphatase Ptpn11 (Shp2) is inhibited or mutated in mice.
    1. Developmental Biology

    Identification and functional characterization of muscle satellite cells in Drosophila

    Dhananjay Chaturvedi et al.
    Modeling adult muscle homeostasis, maintenance and repair will now be possible in Drosophila with the discovery of satellite cells equivalents in flight muscles.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation

    Li Li et al.
    Proteasome-mediated degradation of the TATA-box binding protein (TBP) during terminal differentiation is regulated by the E3 ligase Huwe1 and the deubiquitinase USP10.
    1. Cell Biology

    Caveolae internalization repairs wounded cells and muscle fibers

    Matthias Corrotte et al.
    Cells repair damage to their outer membranes not by patching them as previously thought, but by using proteins called caveolins to remove the damaged regions by endocytosis.
    1. Cancer Biology
    2. Developmental Biology

    PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

    Genevieve C Kendall et al.
    The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.
    1. Human Biology and Medicine

    Stem Cells: Put to the test

    Marites T Woon, Timothy J Kamp
    Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual’s response to potential new drugs before clinical trials.
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    1. Human Biology and Medicine

    Stem Cells: What silent mutations say about the human airways

    Matthew L Donne, Jason R Rock
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    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Neuroscience

    Amyotrophic Lateral Sclerosis: Marking the differences in motoneurons

    Simon A Sharples, Patrick J Whelan
    A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
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    1. Neuroscience

    Intracortical Microstimulation: Regaining the senses of touch and movement

    Victor de Lafuente
    Artificially activating certain neurons in the cortex can make a tetraplegic patient feel naturalistic sensations of skin pressure and arm movement.
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