485 results found
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Deconvoluting heme biosynthesis to target blood-stage malaria parasites

    Paul A Sigala et al.
    Insights into the basic metabolic architecture and adaptations of malaria parasites for growth within human erythrocytes exemplify how incisive knowledge of biochemical pathways and mechanisms may be leveraged to develop new therapies.
    1. Computational and Systems Biology

    Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health

    Michael S Lauer et al.
    An analysis of peer review and funding outcomes of NIH research applications shows that funding disparities of topics preferred by African American Black investigators are not due to peer review preferences or biases.
    1. Neuroscience

    The hippocampus supports deliberation during value-based decisions

    Akram Bakkour et al.
    The deliberation involved in simple preference decisions, such as those between two familiar snacks, depends on the hippocampus.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

    Axelle Marchant et al.
    Regulatory evolution allows paralogs to escape from strucural pleiotropy.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

    Zachary Clemens et al.
    Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
    1. Epidemiology and Global Health

    Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

    Kevin C Ma et al.
    Racial and ethnic disparities in SARS-CoV-2 infection rates can impact overall epidemic dynamics and herd immunity, underscoring the need to develop socially informed transmission models that account for population variability.
    1. Computational and Systems Biology

    Inequalities in the distribution of National Institutes of Health research project grant funding

    Michael S Lauer, Deepshikha Roychowdhury
    Funding inequalities for NIH-supported research project grant investigators and organizations have increased over the past 25 years, but have modestly decreased over the past 3 years.

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