Affinity measurements of microRNA sites representing >1000 different pairing architectures reveal that two binding modes can mediate pairing to the microRNA 3′ region, and that microRNA G and oligo(G/C) residues are most impactful.

A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.

A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

The cyanobacterial core clock tracks midday regardless of day length, which can be understood in terms of a model for how the environment alters the clock limit cycle.

A bulk barcoded quantitative trait locus approach increases the power and resolution of genotype-phenotype mapping in yeast, revealing that the genetic architecture of 18 complex traits is highly polygenic, and is characterized by widespread epistatic interactions and pleiotropic effects.

A technology to produce homogenously poly-ADP-ribosylated proteins reveals key molecular mechanisms that govern ATP-dependent chromatin remodeling activity at DNA damage sites.

Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.

The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.