3,952 results found
    1. Structural Biology and Molecular Biophysics

    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl/H+ transport cycle

    Tanmay S Chavan et al.
    Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Developmental Biology
    2. Neuroscience

    A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells

    Sonal Nagarkar-Jaiswal et al.
    A conditional gene inactivation system that permits the tracking of protein expression, and creates fluorescently-labelled mutant cells in both developing and adult Drosophila tissues.
    1. Microbiology and Infectious Disease

    Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

    Sara Marelli et al.
    Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.
    1. Neuroscience

    Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount

    Mi Shi et al.
    A gene found in Drosophila, and named redeye, encodes a protein that accumulates during sleep deprivation and forms part of the homeostatic system that promotes and maintains sleep.
    1. Cell Biology
    2. Computational and Systems Biology

    Multiple inputs ensure yeast cell size homeostasis during cell cycle progression

    Cecilia Garmendia-Torres et al.
    Yeast cell size homeostasis is not controlled by a G1-specific mechanism alone but is likely to be an emergent property resulting from the integration of several mechanisms that coordinate cell and bud growth with division.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

    Csaba Mihályi et al.
    Coupling of CFTR pore opening to nucleotide binding domain dimerization does not depend on ATP binding, but is an inherent property of the channel protein and likely other ABC transporters.
    1. Computational and Systems Biology
    2. Developmental Biology

    The dynamic transmission of positional information in stau- mutants during Drosophila embryogenesis

    Zhe Yang et al.
    In stau-mutants, the Hunchback boundary shifts posteriorly by 10% EL but shows comparable variability to that of the wild type in short time windows in nuclear cycle 14.
    1. Developmental Biology

    Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

    Yi Xin et al.
    Genetics, in vivo imaging, and unbiased chemical biology screens reveal that Trpv6 functions as a cellular quiescence regulator and delineates a Trpv6-mediated Ca2+ signaling pathway maintaining the quiescent state.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

    Melissa Kane et al.
    Comprehensive investigation reveals the variability and importance of the nuclear pore complex in HIV-1 infection and the activity of the antiretroviral protein, MX2.

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