7,362 results found
    1. Neuroscience

    Neural pattern change during encoding of a narrative predicts retrospective duration estimates

    Olga Lositsky et al.
    Judgments of how much time elapsed between two events in a story are predicted by changes in fMRI activity patterns.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon

    Anna I Vickrey et al.
    Different kinds of molecular changes at one genetic locus control different feather pigmentation patterns, and the darkest patterns resulted from hybridization with another species.
    1. Epidemiology and Global Health

    The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

    Katia Koelle, David A Rasmussen
    Deleterious mutations slow down flu's antigenic evolution, make it more punctuated in nature, and reduce the virus's genetic diversity.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Genomic epidemiology of artemisinin resistant malaria

    MalariaGEN Plasmodium falciparum Community Project
    Plasmodium falciparum kelch13 mutations that cause artemisinin resistant malaria in Southeast Asia show markedly different patterns of evolutionary selection in Africa.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler et al.
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
    1. Genetics and Genomics

    Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

    Hui Zhao et al.
    A comprehensive catalogue of somatic mutations accumulating in MMR-deficient tumors highlights their relevance in the context of human genetic evolution, for the diagnosis of microsatellite instability and the provision of targeted treatment options.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Coevolution-based inference of amino acid interactions underlying protein function

    Victor H Salinas, Rama Ranganathan
    A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
    1. Cancer Biology
    2. Cell Biology

    MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

    Timothy J Aikin et al.
    The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.

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