6,280 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates

    Lucie A Bergeron, Søren Besenbacher ... Mikkel H Schierup
    This first comparison of different methodologies to estimate germline mutation rate from pedigrees resulted in almost a 2-fold variation in the estimated rates, discrepancies mainly caused by different filtering methods.
    1. Evolutionary Biology

    Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate

    Chungang Feng, Mats Pettersson ... Leif Andersson
    The Atlantic herring has the lowest mutation rate yet estimated in a vertebrate species and this partially explains its moderate nucleotide diversity given the large population size.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Bedrock radioactivity influences the rate and spectrum of mutation

    Nathanaëlle Saclier, Patrick Chardon ... Christophe J Douady
    Subterranean isopods endemic to regions with large igneous rock formations have a higher mutation rate and display an excess of mutations that are typical of an oxidative stress.
    1. Genetics and Genomics

    Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation

    Jing Hu, Bingna Zhou ... Mei Li
    Impaired bone microstructure and bone strength are prominent characteristics of rats with hemizygous E10-16del mutation in PLS3, and treatment with alendronate or teriparatide can improve bone mineral density and bone microstructure of this novel rat model with PLS3-related early-onset osteoporosis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Somatic mutation rates scale with time not growth rate in long-lived tropical trees

    Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
    Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses

    Matthew D Pauly, Megan C Procario, Adam S Lauring
    A new assay for specific mutational classes provides preciseestimates of the mutation rates and mutational bias for influenza A viruses.
    1. Microbiology and Infectious Disease

    Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

    Toon Swings, Bram Van den Bergh ... Jan Michiels
    Population mutation rates are highly flexible and evolvable under extreme stress conditions, matching changes in selective pressure to avoid extinction of the entire population.
    1. Genetics and Genomics

    Spontaneous mutations and the origin and maintenance of quantitative genetic variation

    Wen Huang, Richard F Lyman ... Trudy FC Mackay
    Whole genome DNA sequence analysis, genome wide gene expression and complex organismal phenotypes in Drosophila mutation accumulation lines provide a robust estimate of the spontaneous mutation rate and mutational effects.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A broad mutational target explains a fast rate of phenotypic evolution

    Fabrice Besnard, Joao Picao-Osorio ... Marie-Anne Félix
    A broad mutational target is the cause of the high mutational variance and corresponding fast phenotypic evolutionary rate in P3.p cell fate in Caenorhabditis nematodes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice

    Thomas A Sasani, Aaron R Quinlan, Kelley Harris
    Germline mutation rates in mice are shaped by two mutator alleles that interact epistatically, showing that DNA repair defects that map to different loci can have snowballing effects.

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