A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.

Analysis of adenylosuccinate lyase (ADSL) deficiency in multiple experimental systems reveals cell and organismal phenotypes and impaired neurodevelopment due to the attenuation of ADSL's roles in distinct pathways.

ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.

Ptch1/2 can lower the sensitivity of Smo to activation by Shh via the secretion of a sterol precursor.

Overexpression of VPS9D1-AS1 is a lncRNA to activate TGF-β and IFN signaling pathways, regulates crosstalk between cancer cells and T lymphocytes in the tumor microenvironment.

Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.

Combining ribosome profiling and RNA sequencing illuminates novel features of porcine reproductive and respiratory syndrome virus gene expression, including the regulation of polyprotein stoichiometry through temporal modulation of ribosomal frameshifting and the synthesis of non-canonical transcripts.

Targeting a genetically-encoded glutamate sensor to postsynaptic sites demonstrates the feasibility of simultaneous optical quantal analysis of many inputs to a neuron in wide-field fluorescence microscopy.

Ca_V1.3 channels of the short isoform are coupled via their C-terminal domains in a Ca²⁺-CaM-dependent manner, which facilitates Ca²⁺ influx and increases the discharge of hippocampal neurons.