Beatriz Navarro-Dominguez, Ching-Ho Chang ... Amanda M Larracuente
African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
Mathematical modelling suggests that the evolution of communication between bacterial viruses requires repeated outbreak events, and the model then predicts typical communication strategies.
Selection for asymmetric signalling between gametes explains the very origins of sexual asymmetry as seen in mating-types with morphologically similar but self-incompatible gametes.
Michael B Schulte, Jeremy A Draghi ... Raul Andino
A mathematical model that combines stochasticity and spatial structure describes the dynamics of the viral population during an infection cycle, and fitting the model to RNA and virus abundances over time shows that poliovirus follows a geometric replication mode.
Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
Casey K Hua, Albert T Gacerez ... Chris Bailey-Kellogg
The combination of computational modeling and protein design can reveal key determinants of antibody–antigen binding and optimize small sets of antigen variants for efficient experimental localization of epitopes.
Milo S Johnson, Shreyas Gopalakrishnan ... Michael M Desai
Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.
Gene duplication is a useful strategy to reduce intrinsic noise in gene expression, which can provide a selective advantage in scenarios of cost-benefit analysis of expression.
