3,099 results found
    1. Computational and Systems Biology

    Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting

    David Mavor et al.
    Chemical perturbation-dependent deep mutational scanning data collected by a lab-based interdisciplinary graduate class resolves a paradox between the high evolution conservation and the high mutational tolerance of the protein ubiquitin.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A combination of transcription factors mediates inducible interchromosomal contacts

    Seungsoo Kim et al.
    A pooled mutational scanning approach for 3D chromosome conformation reveals how multiple transcription factors can jointly specify condition-specific genome conformations.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

    Bargavi Thyagarajan, Jesse D Bloom
    Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mapping mutational effects along the evolutionary landscape of HIV envelope

    Hugh K Haddox et al.
    Deep mutational scanning of Env proteins from two transmitted-founder strains of HIV shows how the accessible evolutionary space changes as the virus evolves.
    1. Structural Biology and Molecular Biophysics

    Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

    Assaf Elazar et al.
    Deep sequencing analysis quantifies the hydrophobicity of the plasma membrane and provides restraints for structure modeling of receptor homodimers to atomic precision.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans

    YQ Shirleen Soh et al.
    Complete mapping of human-adaptive mutations to the avian influenza PB2 protein shows how selection at key molecular interfaces combines with evolutionary accessibility to shape viral host adaptation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

    Juhye M Lee et al.
    Single viral mutations can escape polyclonal human immunity to influenza hemagglutinin, but different mutations escape the immunity of different people.
    1. Cancer Biology

    Breast Cancer: Targeting mutant estrogen receptors

    Suzanne E Wardell et al.
    A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
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    1. Microbiology and Infectious Disease

    Tropical Diseases: Can CRISPR help in the fight against parasitic worms?

    Paul McVeigh, Aaron G Maule
    The first reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these dangerous human parasites.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Brain Size: Gene losses did not stop the evolution of big brains

    Cristian Cañestro, Vittoria Roncalli
    Elephants and fruit bats have evolved large brains even though they have lost a gene that is fundamental to the supply of energy to the brain when glucose is not available.
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