Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.

Germline mutation rates in mice are shaped by two mutator alleles that interact epistatically, showing that DNA repair defects that map to different loci can have snowballing effects.

Transcribed promoters are highly susceptible to mutation by cytidine deaminases, implicating stable exposure of single stranded DNA structures, rather than cofactors, in localising mutation during tumourigenesis and antibody maturation.

The Atlantic herring has the lowest mutation rate yet estimated in a vertebrate species and this partially explains its moderate nucleotide diversity given the large population size.

Certain mutational signatures vary in their contribution to genetic variation across the yeast phylogeny due to genetically encoded natural mutator phenotypes whose activity can be directly measured in the lab.

A new framework for mutation spectrum analysis reveals multiple independent changes in the germline mutation patterns of human populations, which cannot be explained by shifts in average ages at reproduction.

This first comparison of different methodologies to estimate germline mutation rate from pedigrees resulted in almost a 2-fold variation in the estimated rates, discrepancies mainly caused by different filtering methods.

A rare human mitofusin (MFN) 2 mutation that uniquely impaired Parkin-mediated mitophagy evoked developmental heart disease and increased myocardial sensitivity to doxorubicin in mice, differentiating it from mitophagy-competent MFN2 mutations that cause neuropathy and implicating mitophagy in clinical cardiomyopathy.

Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.

Different types of epigenetic DNA modifications affect the likelihood of cytosine mutations in cancer.