33 results found
  1. May 2015

    Episode 20: May 2015

    In this episode we hear about echolocation, bacteriophages, babies and pain, a neural code for food abundance, and how zebrafish can make their own sunscreen.
    1. Structural Biology and Molecular Biophysics

    Protein denaturation at the air-water interface and how to prevent it

    Edoardo D'Imprima et al.
    Hydrophilized graphene prevents protein denaturation at the air-water interface.
    1. Microbiology and Infectious Disease

    Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

    Aleksandra Agapova et al.
    Metabolomics and stable isotope labelling studies of virulent Mycobacterium tuberculosis reveal a de-centralised metabolic network able to utilise various amino acids as nitrogen sources to a better extent than ammonium.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

    Bridgette M Cumming et al.
    Quantifiable bioenergetic parameters, determined from extracellular flux analyses, are distinct between macrophages infected with Mycobacteriumtuberculosis or vaccine strain M. bovis BCG, enabling assessment of future vaccine and drug efficacy.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex

    Brian Bae et al.
    The crystal structure of Thermus transcription activation complexes containing the transcriptional activator CarD reveals a new mechanism for the activation of transcription.
    1. Microbiology and Infectious Disease

    The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages

    Evgeniya V Nazarova et al.
    An unbiased forward genetic screen identified genes in Mycobacterium tuberculosis that are required for fatty acid import when the bacterium is residing within macrophages.
    1. Microbiology and Infectious Disease

    Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

    Evgeniya V Nazarova et al.
    The integral membrane protein LucA facilitates fatty acid and cholesterol uptake into Mycobacterium tuberculosis by stabilizing the Mce1 and Mce4 transporters, respectively, and Mce1 functions as a fatty acid transporter in Mycobacterium tuberculosis.
    1. Structural Biology and Molecular Biophysics

    Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans

    Jihee Hwang et al.
    RecO efficiently displaces SSB from ssDNA without consuming ATPs using its two DNA-binding sites, even though SSB binds to ssDNA approximately 300 times more strongly than RecO does.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection

    Molly A Matty et al.
    An in vivo drug screen of FDA-approved compounds in zebrafish identified host-directed therapies against mycobacterial infection, including the drug clemastine, which targets the P2RX7-inflammasome axis to enhance bacterial control.
    1. Microbiology and Infectious Disease

    Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

    Saurabh Mishra et al.
    Intrinsic tolerance of Mycobacterium tuberculosis toward the world's most successful antibacterials, β-lactams, is dependent on cytoplasmic redox potential and an intracellular redox-sensor WhiB4.

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