Browse the search results

Oligodendroglia express major histocompatibility complex (MHC) pathways in response to inflammation and MHC reporter mice allow for the investigation of MHC molecule expressing cells in vivo.

A curated resource to study the brain RNA expression patterns of the genes that regulate palmitoylation is presented, alongside a detailed exploration of how these patterns can inform future research.

A protein microarray based strategy has identified a bacterial enzyme that represents a new protein deacetylase family.

Oligodendrocyte-lineage cells secrete L-type prostaglandin synthase in an autocrine loop to promote oligodendrocyte development and myelination.

Two novel subsets of microglia identified by their unique autofluorescence profiles differ in their subcellular organization, proteomic signatures and in their response to aging and lysosomal dysfunction.

A proteo-genomic CRISPR activation screening workflow to accelerate the identification of novel interactions between the secreted and membrane proteome with the potential to define new biological processes and identify future therapeutic targets.

Mature myelin sheaths are scaffolded by the anillin-dependent assembly of septin filaments, thereby facilitating rapid nerve conduction in the healthy CNS.

A dynamic SILAC analysis reveals that neuronal proteome turnover is influenced by the cell type as well as the extracellular environment.

High PI3K-Akt-mTORC1 activity inhibits Schwann cell differentiation, while after onset of myelination, residual PI3K-Akt-mTORC1 activity promotes myelin growth.

H-ABC leukodystrophy results in neurologic decline, hypomyelination and atrophy of the striatum and cerebellum and Tubb4a^D249N/D249Nmouse model recapitulates features of H-ABC disease, providing an important tool for therapeutic development.