177 results found
    1. Neuroscience

    Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

    Xiaohui Yan et al.
    Convergent structural and functional brain deficits associated with dyslexia were found in left superior temporal gyrus across languages, however, language-specific deficits were also identified.
    1. Neuroscience

    Modeling spinal locomotor circuits for movements in developing zebrafish

    Yann Roussel et al.
    Computational models of spinal locomotor circuits in developing zebrafish reveal how new movements can emerge during development through the integration of new spinal neurons and new connections.
    1. Neuroscience

    Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

    Oshri Avraham et al.
    The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.
    1. Neuroscience

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    Gustavo Della-Flora Nunes et al.
    mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee et al.
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

    Richard Gao et al.
    Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
    1. Cell Biology
    2. Developmental Biology

    The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation

    Xiaoling Li et al.
    A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell growth and blood–brain barrier integrity in a highly coordinated spatiotemporal manner in brain homeostasis.
    1. Immunology and Inflammation

    Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

    Isobel C Mouat et al.
    Latent gammaherpesvirus infection predisposes mice to develop more severe disease following induction of arthritis by elevating pathogenic interferon-gamma-expressing age-associated B cells.
    1. Developmental Biology

    An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

    Zhaoyang Liu et al.
    The regulation of the biomechanical properties of tendons/ligaments is essential for the maintenance of spine alignment in the mouse.

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