414 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

    Amy W Ku et al.
    Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.
    1. Cancer Biology

    Philosophy of Biology: Characterizing causality in cancer

    Elena Rondeau et al.
    Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

    Helene Rundqvist et al.
    Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
    1. Cancer Biology
    2. Immunology and Inflammation

    Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Biancamaria Ricci et al.
    Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.
    1. Cancer Biology

    MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans

    Calvin VanOpstall et al.
    The HOXB13 binding partner MEIS1 suppresses prostate cancer proliferation, invasion, and metastasis by promoting expression of the anti-oncogenic extracellular proteoglycan Decorin.
    1. Immunology and Inflammation
    2. Neuroscience

    A new genetic strategy for targeting microglia in development and disease

    Gabriel L McKinsey et al.
    P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.
    1. Computational and Systems Biology
    2. Neuroscience

    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

    Amin Haghani et al.
    Transcriptome analysis of mouse brain revealed that the APOE4 allele and sex can alter air pollution neurotoxicity in adults.
    1. Cancer Biology
    2. Immunology and Inflammation

    The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

    Aaron R Lim et al.
    Diverse components of the tumor microenvironment affect T cell metabolism in ways that are crucial to improving immunotherapy.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

    Keisuke Kitakaze et al.
    Cell-based high-throughput screening identifies IBT21 as a chemical chaperone, that inhibits ER protein aggregation and prevents the cell death caused by a proteotoxin, the aggregation-prone prion protein.

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